A guide to numerical modelling in systems biology [electronic resource]

• 作者： Deuflhard, Peter.
• 其他作者：
  • Roblitz, Susanna.
  • SpringerLink (Online service)
• 其他題名：
  • Texts in computational science and engineering,
• 出版： Cham : Springer International Publishing :Imprint: Springer
• 叢書名： Texts in computational science and engineering,12
• 主題： Systems biology--Mathematical models. , Bioinformatics , Differential equations , Mathematics , Ordinary Differential Equations. , Applications of Mathematics. , Mathematical and Computational Biology. , Simulation and Modeling. , Numerical and Computational Physics.
• ISBN： 9783319200590 (electronic bk.) 、 9783319200583 (paper)
• FIND@SFXID: CGU
• 資料類型: 電子書
• 內容註: Preface -- Outline -- ODE Models for Systems Biological Networks -- Numerical Simulation of ODE Models -- Parameter Identification in ODE Models -- Appendix -- Software -- Index.
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• 摘要註: This book is intended for students of computational systems biology with only a limited background in mathematics. Typical books on systems biology merely mention algorithmic approaches, but without offering a deeper understanding. On the other hand, mathematical books are typically unreadable for computational biologists. The authors of the present book have worked hard to fill this gap. The result is not a book on systems biology, but on computational methods in systems biology. This book originated from courses taught by the authors at Freie Universitat Berlin. The guiding idea of the courses was to convey those mathematical insights that are indispensable for systems biology, teaching the necessary mathematical prerequisites by means of many illustrative examples and without any theorems. The three chapters cover the mathematical modelling of biochemical and physiological processes, numerical simulation of the dynamics of biological networks, and identification of model parameters by means of comparisons with real data. Throughout the text, the strengths and weaknesses of numerical algorithms with respect to various systems biological issues are discussed. Web addresses for downloading the corresponding software are also included.
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