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A short history of the drug receptor concept [electronic resource]
- 作者： Prèull, Cay-Rèudiger.
- 其他作者：
- 出版： Basingstoke [England] ;New York : Palgrave Macmillan
- 叢書名： Science, technology, and medicine in modern history
- 主題： Drug receptors--History. , Receptors, Drug--history. , Biomedical Research--history. , History, 19th Century. , History, 20th Century. , Pharmacology--History. , Electronic books.
- ISBN： 9780230583740 、 0230583741
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FIND@SFXID:
CGU
- 資料類型: 電子書
- 內容註: Includes bibliographical references and index. Paul Ehrlich and his receptor concept -- The development of the concept of drug receptors in the physiological research of J.N. Langley -- The receptors and scientific pharmacology I : the critics of the receptor idea and alternative theories of drug action, c. 1905-1935 -- The receptors and scientific pharmacology II : the critics of the receptor idea and alternative research strands : thetransmitter theory, c. 1905-1935 -- Quantitative arguments for the existence of drug receptors and the development of the receptor occupancy theory, c. 1910-1960 -- The dual adrenaline receptor theory of Raymond P. Ahlquist (1914-1983) and its application in drug development between 1950 and 1970 -- The emergence of molecular pharmacology.
- 摘要註: Humans have long used plant and animal extracts for their medicinal properties but until the end of the 19th century their actions were often explained in a speculative manner. The systematic study of drugs didnot begin until the 1860s, and the concept of receptors as the target of their effects in the body only emerged at the end of the 19th century from the brilliant and independent studies of John Newport Langley (1852-1925) and Paul Ehrlich (1854-1915). This book address the people and the key discoveries that led to the development of the receptor concept and its impact on 20th-century medicine: A.J Clark in the 1930s, andlater E.J Ariens and R.P Stephenson in the 1950s provided the quantitative basis of drug receptor occupancy theory. R.P Ahlquist's investigations gave rise tothe proposal of receptor subtypes in 1948 and facilitated Sir James Black (and subsequently others)to apply the receptor concept to clinical therapy (beta blockers) in the mid 1960s. By the early 1980s, the first (acetylcholine) receptor had been isolated and cloned. Today, we recognize a large and diverse number of physiological receptors which can be delineated into 'receptor super-families' on the basis of their pharmacology and molecular properties. These receptors are now the focus of a multi-national, multi-billion dollar pharmaceutical industry. This book reveals that these successes were by no means foreseeable, since chance, coincidence, competition among scientists, and other factors played important roles in the history of the receptor concept.
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讀者標籤：
- 系統號： 005053287 | 機讀編目格式
館藏資訊
The concept of specific receptors for drugs, hormones and transmitters lies at the very heart of biomedicine. This book is the first to consider the idea from its 19th century origins in the work of John Newport Langley and Paul Ehrlich, to its development of during the 20th century and its current impact on drug discovery in the 21st century.
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